Research workbench

Human factor inhibiting hif (FIH1) in complex with 2-oxoglutarate

Analyse Human factor inhibiting hif (FIH1) in complex with 2-oxoglutarate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MZF
Type: protein
Length: 335 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Factor inhibiting HIF1
UniProt: Q9NWT6
Ligands: AKG, FE2
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Factor inhibiting HIF1	protein	335	30% helix, 25% strand	Q9NWT6

Ligands and binding sites

AKG · 2-oxoglutaric acid · ligand · chains A
FE2 · Fe (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	402	0.67	0.80	41	FE2, AKG
2	65	0.45	0.83	17	empty
3	150	0.44	0.75	27	empty
4	118	0.40	0.75	24	empty

Compared structures

1MZF · Human Factor inhibiting HIF (FIH1) in Complex with 2-oxoglutarate · the same entry in another collection · chain A against A, TM-score 1.00
Q9NWT6 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha inhibitor (Q9NWT6) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NWT6
Elsewhere: RCSB PDB 1MZF · PDBe 1MZF · UniProt Q9NWT6

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