Research workbench

Crystal structure of human pro-granzyme K

Analyse Crystal structure of human pro-granzyme K in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MZD
Type: protein
Length: 240 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pro-granzyme K
EC: 3.4.21.-
UniProt: P49863
Pockets: 3 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pro-granzyme K (EC 3.4.21.-)	protein	240	6% helix, 31% strand	P49863

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	190	0.51	0.77	31	empty
2	144	0.44	0.76	30	empty
3	63	0.40	0.81	25	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1MZD · crystal structure of human pro-granzyme K · the same entry in another collection · chain A against A, TM-score 1.00
P49863 · AlphaFold monomer V2.0 prediction for granzyme K (P49863) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49863
Elsewhere: RCSB PDB 1MZD · PDBe 1MZD · UniProt P49863

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.