Research workbench
MDM2 bound cueo-PM2 sensor
Analyse MDM2 bound cueo-PM2 sensor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IM9
- Type
- protein
- Length
- 577 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Blue copper oxidase CUEO,PM2 PEPTIDE,BLUE copper oxidase cueo; E3 ubiquitin-protein…
- EC
- 2.3.2.27
- UniProt
- P36649, Q00987
- Pockets
- 7 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Blue copper oxidase CUEO,PM2 PEPTIDE,BLUE copper oxidase cueo | protein | 490 | 12% helix, 39% strand | P36649 |
| B | E3 ubiquitin-protein ligase MDM2 (EC 2.3.2.27) | protein | 87 | 44% helix, 18% strand | Q00987 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 324 | 0.61 | 0.78 | 30 | empty |
| 2 | 69 | 0.52 | 0.86 | 24 | empty |
| 3 | 64 | 0.48 | 0.84 | 17 | empty |
| 4 | 122 | 0.47 | 0.79 | 27 | empty |
| 5 | 91 | 0.39 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 826 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36649
- Every structure of UniProt Q00987
- Elsewhere: RCSB PDB 6IM9 · PDBe 6IM9 · UniProt P36649 · UniProt Q00987
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