Research workbench
Crystal structure of H7 hemagglutinin from A/ANHUI/1/2013 in complex with a human neutralizing antibody L4A-14
Analyse Crystal structure of H7 hemagglutinin from A/ANHUI/1/2013 in complex with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6II4
- Type
- protein
- Length
- 1,828 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin; Heavy chain of L4A-14 Fab; Light chain of L4A-14 Fab
- UniProt
- A0A024CX39, A0A0K1LUI9
- Pockets
- 19 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 14% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Hemagglutinin | protein | 316 | 9% helix, 35% strand | A0A024CX39 |
| B, D | Hemagglutinin | protein | 166 | 52% helix, 7% strand | A0A0K1LUI9 |
| E, H | Heavy chain of L4A-14 Fab | protein | 220 | 1% helix, 47% strand | — |
| F, L | Light chain of L4A-14 Fab | protein | 212 | 5% helix, 46% strand | — |
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1101 | 0.75 | 0.78 | 105 | empty |
| 2 | 224 | 0.64 | 0.83 | 25 | empty |
| 3 | 209 | 0.62 | 0.82 | 24 | empty |
| 4 | 444 | 0.58 | 0.74 | 54 | empty |
| 5 | 231 | 0.51 | 0.76 | 37 | empty |
Interfaces
10 interfaces between chains.
- A–B · 3008 Ų buried · 36 hydrogen bonds · protein-protein
- C–D · 2969 Ų buried · 43 hydrogen bonds · protein-protein
- E–F · 1682 Ų buried · 16 hydrogen bonds · protein-protein
- H–L · 1607 Ų buried · 14 hydrogen bonds · protein-protein
- C–E · 662 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 6II4 · Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024CX39
- Every structure of UniProt A0A0K1LUI9
- Elsewhere: RCSB PDB 6II4 · PDBe 6II4 · UniProt A0A024CX39 · UniProt A0A0K1LUI9
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