Research workbench
Crystal structure of myelin protein zero-like protein 1 (MPZL1)
Analyse Crystal structure of myelin protein zero-like protein 1 (MPZL1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IGO
- Type
- protein
- Length
- 719 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myelin protein zero-like protein 1
- UniProt
- O95297
- Pockets
- 6 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Myelin protein zero-like protein 1 | protein | 122 | 5% helix, 49% strand | O95297 |
| A, D | Myelin protein zero-like protein 1 | protein | 120 | 5% helix, 49% strand | O95297 |
| B, E, F | Myelin protein zero-like protein 1 | protein | 119 | 8% helix, 50% strand | O95297 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 996 | 0.73 | 0.77 | 90 | empty |
| 2 | 167 | 0.64 | 0.85 | 24 | empty |
| 3 | 116 | 0.56 | 0.84 | 24 | empty |
| 4 | 73 | 0.38 | 0.78 | 14 | empty |
| 5 | 64 | 0.30 | 0.75 | 10 | empty |
Interfaces
8 interfaces between chains.
- B–D · 1021 Ų buried · 10 hydrogen bonds · protein-protein
- C–A · 1019 Ų buried · 11 hydrogen bonds · protein-protein
- D–E · 442 Ų buried · 4 hydrogen bonds · protein-protein
- C–E · 404 Ų buried · 5 hydrogen bonds · protein-protein
- B–F · 374 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6IGO · Crystal structure of myelin protein zero-like protein 1 (MPZL1) · the same entry in another collection · chain F against F, TM-score 1.00
- O95297 · AlphaFold monomer V2.0 prediction for myelin protein zero-like protein 1 (O95297) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95297
- Elsewhere: RCSB PDB 6IGO · PDBe 6IGO · UniProt O95297
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