Research workbench
Crystal structure of argininosuccinate lyase from mycobacterium tuberculosis
Analyse Crystal structure of argininosuccinate lyase from mycobacterium tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IG5
- Type
- protein
- Length
- 1,820 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Argininosuccinate lyase
- EC
- 4.3.2.1
- UniProt
- P9WPY7
- Pockets
- 18 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 69% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Argininosuccinate lyase (EC 4.3.2.1) | protein | 455 | 69% helix, 5% strand | P9WPY7 |
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 723 | 0.79 | 0.84 | 66 | empty |
| 2 | 730 | 0.79 | 0.83 | 77 | empty |
| 3 | 758 | 0.78 | 0.82 | 65 | empty |
| 4 | 774 | 0.77 | 0.81 | 66 | empty |
| 5 | 314 | 0.61 | 0.78 | 43 | empty |
Interfaces
6 interfaces between chains.
- B–D · 4060 Ų buried · 66 hydrogen bonds · protein-protein
- A–C · 3961 Ų buried · 70 hydrogen bonds · protein-protein
- C–D · 1774 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 1762 Ų buried · 31 hydrogen bonds · protein-protein
- A–D · 1744 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6IG5 · Crystal structure of argininosuccinate lyase from Mycobacterium tuberculosis · the same entry in another collection · chain D against D, TM-score 1.00
- P9WPY7 · AlphaFold monomer V2.0 prediction for argininosuccinate lyase (P9WPY7) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WPY7
- Elsewhere: RCSB PDB 6IG5 · PDBe 6IG5 · UniProt P9WPY7
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