Research workbench
Structure of rvfv gn and human monoclonal antibody R12
Analyse Structure of rvfv gn and human monoclonal antibody R12 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IEK
- Type
- protein
- Length
- 1,484 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nsmgngc; Heavy chain of Fab R12; Light chain of Fab R12
- UniProt
- H9BSP3
- Pockets
- 18 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Nsmgngc | protein | 301 | 14% helix, 31% strand | H9BSP3 |
| B, E | Heavy chain of Fab R12 | protein | 223 | 4% helix, 48% strand | — |
| C, F | Light chain of Fab R12 | protein | 218 | 8% helix, 48% strand | — |
Pockets
18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 856 | 0.75 | 0.79 | 83 | empty |
| 2 | 788 | 0.75 | 0.80 | 92 | empty |
| 3 | 1063 | 0.71 | 0.75 | 93 | empty |
| 4 | 151 | 0.67 | 0.88 | 28 | empty |
| 5 | 629 | 0.64 | 0.74 | 57 | empty |
Interfaces
9 interfaces between chains.
- B–C · 1893 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 1850 Ų buried · 8 hydrogen bonds · protein-protein
- A–F · 452 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 435 Ų buried · 9 hydrogen bonds · protein-protein
- D–F · 415 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 26 disulfide (disulfide).
Compared structures
- 6IEK · Structure of RVFV Gn and human monoclonal antibody R12 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H9BSP3
- Elsewhere: RCSB PDB 6IEK · PDBe 6IEK · UniProt H9BSP3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.