Research workbench
Crystal structure of H7 hemagglutinin mutant H7-avtl (P221T) from the influenza virus A/ANHUI/1/2013 (H7N9)
Analyse Crystal structure of H7 hemagglutinin mutant H7-avtl (P221T) from the influenza… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ID2
- Type
- protein
- Length
- 2,868 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin HA1 chain; Hemagglutinin HA2 chain
- UniProt
- R4NN21
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 17% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Hemagglutinin HA1 chain | protein | 314 | 8% helix, 39% strand | R4NN21 |
| B, D, F, H, J, L | Hemagglutinin HA2 chain | protein | 163 | 51% helix, 11% strand | R4NN21 |
| G, I, K | Hemagglutinin HA1 chain | protein | 316 | 8% helix, 40% strand | R4NN21 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1188 | 0.84 | 0.85 | 113 | empty |
| 2 | 986 | 0.83 | 0.84 | 97 | empty |
| 3 | 170 | 0.82 | 0.97 | 25 | empty |
| 4 | 170 | 0.82 | 0.97 | 26 | empty |
| 5 | 155 | 0.81 | 0.97 | 26 | empty |
Interfaces
33 interfaces between chains.
- G–H · 3266 Ų buried · 43 hydrogen bonds · protein-protein
- I–J · 3224 Ų buried · 37 hydrogen bonds · protein-protein
- K–L · 3186 Ų buried · 42 hydrogen bonds · protein-protein
- A–B · 3041 Ų buried · 34 hydrogen bonds · protein-protein
- C–D · 2991 Ų buried · 30 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 disulfide (disulfide).
Compared structures
- 6ID2 · Crystal structure of H7 hemagglutinin mutant H7-AVTL (P221T) from the influenza virus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt R4NN21
- Elsewhere: RCSB PDB 6ID2 · PDBe 6ID2 · UniProt R4NN21
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