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Crystal structure of hamster mif

Analyse Crystal structure of hamster mif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ICE
Type: protein
Length: 344 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrophage migration inhibitory factor
UniProt: A0A140EDM8
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrophage migration inhibitory factor	protein	116	38% helix, 30% strand	A0A140EDM8
B, C	Macrophage migration inhibitory factor	protein	114	39% helix, 31% strand	A0A140EDM8

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	612	0.82	0.87	67	empty
2	52	0.54	0.88	12	empty
3	58	0.51	0.86	13	empty

Interfaces

3 interfaces between chains.

B–C · 1137 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 1122 Å² buried · 19 hydrogen bonds · protein-protein
A–C · 1106 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

6ICE · Crystal structure of Hamster MIF · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A140EDM8
Elsewhere: RCSB PDB 6ICE · PDBe 6ICE · UniProt A0A140EDM8

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