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Circular permutant of ribosomal protein S6, adding 9AA to N terminal of P81-82, L75A mutant

Analyse Circular permutant of ribosomal protein S6, adding 9AA to N terminal of P81-82… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6I6U
Type: protein
Length: 204 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 30S ribosomal protein S6,30S ribosomal protein S6
UniProt: Q5SLP8
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	30S ribosomal protein S6,30S ribosomal protein S6	protein	99	27% helix, 45% strand	Q5SLP8
B	30S ribosomal protein S6,30S ribosomal protein S6	protein	105	36% helix, 43% strand	Q5SLP8

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	368	0.77	0.87	44	empty
2	292	0.72	0.85	36	empty
3	91	0.36	0.75	21	empty

Interfaces

1 interface between chains.

A–B · 1625 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

6I6U · Circular permutant of ribosomal protein S6, adding 9aa to N terminal of P81-82, L75A… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SLP8
Elsewhere: RCSB PDB 6I6U · PDBe 6I6U · UniProt Q5SLP8

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