Research workbench

Papaver somniferum O-methyltransferase 1

Analyse Papaver somniferum O-methyltransferase 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6I5Q
Type: protein
Length: 1,372 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: O-methyltransferase 1
UniProt: I3PLQ5
Pockets: 13 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	O-methyltransferase 1	protein	342	49% helix, 13% strand	I3PLQ5
D	O-methyltransferase 1	protein	346	48% helix, 16% strand	I3PLQ5

Pockets

13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	927	0.77	0.79	70	empty
2	857	0.75	0.79	68	empty
3	764	0.74	0.79	56	empty
4	726	0.72	0.78	57	empty
5	492	0.62	0.76	51	empty

Interfaces

3 interfaces between chains.

A–B · 4089 Å² buried · 28 hydrogen bonds · protein-protein
C–D · 4072 Å² buried · 25 hydrogen bonds · protein-protein
A–C · 542 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6I5Q · Papaver somniferum O-methyltransferase 1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I3PLQ5
Elsewhere: RCSB PDB 6I5Q · PDBe 6I5Q · UniProt I3PLQ5

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