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Structure, dynamics and ROX2-lncrna binding of tandem double-stranded RNA binding domains DSRBD1/2 of drosophila helicase mle

Analyse Structure, dynamics and ROX2-lncrna binding of tandem double-stranded RNA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6I3R
Type: protein
Length: 259 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dosage compensation regulator
EC: 3.6.4.13
UniProt: P24785
Pockets: 3 · best druggability 0.56

Structure

solution nmr · 1 distinct chain · 30% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dosage compensation regulator (EC 3.6.4.13)	protein	259	30% helix, 14% strand	P24785

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	185	0.56	0.80	25	empty
2	106	0.44	0.78	23	empty
3	134	0.41	0.75	18	empty

Compared structures

6I3R · Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains… · the same entry in another collection · chain A against A, TM-score 1.00
P24785 · AlphaFold monomer V2.0 prediction for dosage compensation regulator (P24785) · a predicted model of the same protein · chain A against A, TM-score 0.34

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P24785
Elsewhere: RCSB PDB 6I3R · PDBe 6I3R · UniProt P24785

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