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Crystal structure of reactive center loop (rcl) cleaved angiotensinogen

Analyse Crystal structure of reactive center loop (rcl) cleaved angiotensinogen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6I3I
Type: protein
Length: 428 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiotensinogen
UniProt: P01019
Ligands: NAG
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Angiotensinogen	protein	428	32% helix, 29% strand	P01019

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.52	0.76	28	empty
2	84	0.39	0.78	21	empty
3	70	0.36	0.78	18	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6I3I · Crystal structure of reactive center loop (RCL) cleaved angiotensinogen · the same entry in another collection · chain A against A, TM-score 1.00
P01019 · AlphaFold monomer V2.0 prediction for angiotensinogen (P01019) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01019
Elsewhere: RCSB PDB 6I3I · PDBe 6I3I · UniProt P01019

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