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Structure of P18INK4C (F82Q)

Analyse Structure of P18INK4C (F82Q) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MX4
Type: protein
Length: 315 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cyclin-dependent kinase 6 inhibitor
UniProt: P42773
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cyclin-dependent kinase 6 inhibitor	protein	156	51% helix, 1% strand	P42773
B	Cyclin-dependent kinase 6 inhibitor	protein	159	52% helix, 1% strand	P42773

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.32	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 339 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1MX4 · Structure of p18INK4c (F82Q) · the same entry in another collection · chain A against A, TM-score 1.00
P42773 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 4 inhibitor C (P42773) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42773
Elsewhere: RCSB PDB 1MX4 · PDBe 1MX4 · UniProt P42773

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