Research workbench
The structure of the hypothetical protein HI1388.1 from haemophilus influenzae reveals a TAUTOMERASE/MIF fold
Analyse The structure of the hypothetical protein HI1388.1 from haemophilus influenzae… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MWW
- Type
- protein
- Length
- 358 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein HI1388.1
- UniProt
- O86237
- Ligands
- GLU, CL
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Hypothetical protein HI1388.1 | protein | 120 | 43% helix, 29% strand | O86237 |
| B | Hypothetical protein HI1388.1 | protein | 118 | 43% helix, 30% strand | O86237 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.74 | 0.98 | 32 | empty |
| 2 | 220 | 0.60 | 0.81 | 23 | GLU |
| 3 | 196 | 0.60 | 0.81 | 21 | empty |
| 4 | 257 | 0.54 | 0.76 | 28 | empty |
| 5 | 153 | 0.53 | 0.80 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1244 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1211 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 1201 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 1MWW · The structure of the hypothetical protein HI1388.1 from haemophilus influenzae reveals a… · the same entry in another collection · chain A against A, TM-score 1.00
- O86237 · AlphaFold monomer V2.0 prediction for uncharacterized protein HI_1388.1 (O86237) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O86237
- Elsewhere: RCSB PDB 1MWW · PDBe 1MWW · UniProt O86237
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