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Crystal structure of the head domain of human CCDC61

Analyse Crystal structure of the head domain of human CCDC61 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6HXT
Type: protein
Length: 365 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coiled-coil domain-containing protein 61
UniProt: Q9Y6R9
Pockets: 5 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 25% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Coiled-coil domain-containing protein 61	protein	118	25% helix, 49% strand	Q9Y6R9
B	Coiled-coil domain-containing protein 61	protein	120	26% helix, 49% strand	Q9Y6R9
C	Coiled-coil domain-containing protein 61	protein	127	24% helix, 46% strand	Q9Y6R9

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.71	0.97	23	empty
2	50	0.36	0.80	13	empty
3	76	0.33	0.75	20	empty
4	63	0.32	0.75	15	empty
5	67	0.27	0.72	17	empty

Interfaces

3 interfaces between chains.

A–B · 907 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 599 Å² buried · 20 hydrogen bonds · protein-protein
A–C · 478 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 modified (engineered).

Compared structures

6HXT · Crystal structure of the head domain of human CCDC61 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y6R9 · AlphaFold monomer V2.0 prediction for centrosomal protein CCDC61 (Q9Y6R9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y6R9
Elsewhere: RCSB PDB 6HXT · PDBe 6HXT · UniProt Q9Y6R9

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