Research workbench
Crystal structure of human ACBD3 gold domain in complex with 3A protein of rhinovirus-14 (HRV14)
Analyse Crystal structure of human ACBD3 gold domain in complex with 3A protein of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HLT
- Type
- protein
- Length
- 332 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Golgi resident protein GCP60; Genome polyprotein
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- Q9H3P7, P03303
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Golgi resident protein GCP60 | protein | 126 | 9% helix, 54% strand | Q9H3P7 |
| B, D | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 40 | 48% helix, 18% strand | P03303 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 137 | 0.59 | 0.83 | 18 | empty |
| 2 | 115 | 0.41 | 0.76 | 15 | empty |
| 3 | 89 | 0.40 | 0.77 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1436 Ų buried · 29 hydrogen bonds · protein-protein
- C–D · 1418 Ų buried · 29 hydrogen bonds · protein-protein
- B–D · 405 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6HLT · Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of rhinovirus-14… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H3P7 · AlphaFold monomer V2.0 prediction for golgi resident protein GCP60 (Q9H3P7) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3P7
- Every structure of UniProt P03303
- Elsewhere: RCSB PDB 6HLT · PDBe 6HLT · UniProt Q9H3P7 · UniProt P03303
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