Research workbench
Structure of universal stress protein from archaeoglobus fulgidus
Analyse Structure of universal stress protein from archaeoglobus fulgidus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HCD
- Type
- protein
- Length
- 532 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Universal stress protein
- UniProt
- O29432
- Ligands
- UNL, CL
- Pockets
- 8 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Universal stress protein | protein | 133 | 43% helix, 23% strand | O29432 |
| B, C | Universal stress protein | protein | 132 | 43% helix, 20% strand | O29432 |
| D | Universal stress protein | protein | 135 | 42% helix, 20% strand | O29432 |
Ligands and binding sites
- UNL · Unknown ligand · ligand · 4 copies · chains A, B, C, D
- CL · Chloride ion · ion · 9 copies · chains A, B, D, C
- ACT · Acetate ion · additive · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 511 | 0.69 | 0.79 | 51 | UNL, ACT |
| 2 | 333 | 0.62 | 0.79 | 29 | empty |
| 3 | 205 | 0.60 | 0.81 | 31 | UNL, CL |
| 4 | 183 | 0.58 | 0.81 | 23 | UNL, CL |
| 5 | 127 | 0.56 | 0.83 | 21 | UNL, CL |
Interfaces
5 interfaces between chains.
- A–B · 1140 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1133 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 465 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 288 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 189 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 6HCD · Structure of universal stress protein from Archaeoglobus fulgidus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O29432
- Elsewhere: RCSB PDB 6HCD · PDBe 6HCD · UniProt O29432
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