Research workbench
Crystal structure of human mediator subunit MED23
Analyse Crystal structure of human mediator subunit MED23 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6H02
- Type
- protein
- Length
- 1,457 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mediator of RNA polymerase II transcription subunit 23; Lama nanobody NB106
- UniProt
- Q9ULK4
- Pockets
- 20 · best druggability 0.89
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mediator of RNA polymerase II transcription subunit 23 | protein | 1334 | 62% helix, 1% strand | Q9ULK4 |
| B | Lama nanobody NB106 | protein | 123 | 7% helix, 50% strand | — |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1009 | 0.89 | 0.91 | 132 | empty |
| 2 | 159 | 0.78 | 0.95 | 28 | empty |
| 3 | 210 | 0.74 | 0.89 | 40 | empty |
| 4 | 67 | 0.74 | 0.98 | 18 | empty |
| 5 | 105 | 0.69 | 0.92 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 992 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6H02 · Crystal structure of human Mediator subunit MED23 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9ULK4 · AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ULK4
- Elsewhere: RCSB PDB 6H02 · PDBe 6H02 · UniProt Q9ULK4
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