Research workbench

The crystal structure of hfq from caulobacter crescentus

Analyse The crystal structure of hfq from caulobacter crescentus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6GWK
Type: protein
Length: 1,651 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-binding protein hfq
UniProt: Q9A7H8
Pockets: 11 · best druggability 0.76

Structure

x-ray diffraction · 15 distinct chains · 21% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, I, W	RNA-binding protein hfq	protein	63	22% helix, 51% strand	Q9A7H8
B, D, J, P, V	RNA-binding protein hfq	protein	77	18% helix, 42% strand	Q9A7H8
C	RNA-binding protein hfq	protein	69	20% helix, 46% strand	Q9A7H8
E	RNA-binding protein hfq	protein	67	16% helix, 48% strand	Q9A7H8
F, O	RNA-binding protein hfq	protein	68	21% helix, 44% strand	Q9A7H8
G	RNA-binding protein hfq	protein	64	23% helix, 45% strand	Q9A7H8
H, N	RNA-binding protein hfq	protein	76	20% helix, 37% strand	Q9A7H8
K	RNA-binding protein hfq	protein	60	25% helix, 52% strand	Q9A7H8
L	RNA-binding protein hfq	protein	70	21% helix, 44% strand	Q9A7H8
M	RNA-binding protein hfq	protein	66	21% helix, 48% strand	Q9A7H8
Q	RNA-binding protein hfq	protein	61	23% helix, 52% strand	Q9A7H8
R	RNA-binding protein hfq	protein	71	20% helix, 46% strand	Q9A7H8
S, U	RNA-binding protein hfq	protein	62	23% helix, 52% strand	Q9A7H8
T	RNA-binding protein hfq	protein	70	17% helix, 37% strand	Q9A7H8
X	RNA-binding protein hfq	protein	67	21% helix, 48% strand	Q9A7H8

Pockets

11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	674	0.76	0.81	56	empty
2	634	0.75	0.81	78	empty
3	654	0.74	0.80	72	empty
4	868	0.71	0.76	66	empty
5	928	0.71	0.75	66	empty

Interfaces

37 interfaces between chains.

N–R · 1149 Å² buried · 18 hydrogen bonds · protein-protein
H–L · 1138 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 1137 Å² buried · 14 hydrogen bonds · protein-protein
T–X · 1121 Å² buried · 14 hydrogen bonds · protein-protein
O–P · 1117 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6GWK · The crystal structure of Hfq from Caulobacter crescentus · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9A7H8
Elsewhere: RCSB PDB 6GWK · PDBe 6GWK · UniProt Q9A7H8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.