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Solution structure of GRO(SLASH)MELANOMA growth stimulatory activity determined by 1H NMR spectroscopy
Analyse Solution structure of GRO(SLASH)MELANOMA growth stimulatory activity determined… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MSH
- Type
- protein
- Length
- 144 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human melanoma growth stimulatory activity
- UniProt
- P09341
- Pockets
- 4 · best druggability 0.64
Structure
solution nmr · 1 distinct chain · 15% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Human melanoma growth stimulatory activity | protein | 72 | 15% helix, 18% strand | P09341 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 209 | 0.64 | 0.83 | 54 | empty |
| 2 | 53 | 0.32 | 0.77 | 16 | empty |
| 3 | 71 | 0.31 | 0.74 | 20 | empty |
| 4 | 64 | 0.30 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 725 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1MSH · Solution structure of GRO(SLASH)MELANOMA growth stimulatory activity determined by 1H NMR… · the same entry in another collection · chain A against A, TM-score 1.00
- P09341 · AlphaFold monomer V2.0 prediction for growth-regulated alpha protein (P09341) · a predicted model of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09341
- Elsewhere: RCSB PDB 1MSH · PDBe 1MSH · UniProt P09341
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