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Solution structure of GRO(SLASH)MELANOMA growth stimulatory activity determined by 1H NMR spectroscopy

Analyse Solution structure of GRO(SLASH)MELANOMA growth stimulatory activity determined… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MSG
Type: protein
Length: 144 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human melanoma growth stimulatory activity
UniProt: P09341
Pockets: 1 · best druggability 0.28

Structure

solution nmr · 1 distinct chain · 15% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Human melanoma growth stimulatory activity	protein	72	15% helix, 21% strand	P09341

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.28	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 655 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1MSG · Solution structure of GRO(SLASH)MELANOMA growth stimulatory activity determined by 1H NMR… · the same entry in another collection · chain A against A, TM-score 1.00
P09341 · AlphaFold monomer V2.0 prediction for growth-regulated alpha protein (P09341) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09341
Elsewhere: RCSB PDB 1MSG · PDBe 1MSG · UniProt P09341

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