Research workbench
Structure of human galactose-1-phosphate uridylyltransferase (galt), with crystallization epitope mutations A21Y:A22T:T23P:R25L
Analyse Structure of human galactose-1-phosphate uridylyltransferase (galt), with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GQD
- Type
- protein
- Length
- 344 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galactose-1-phosphate uridylyltransferase
- EC
- 2.7.7.12
- UniProt
- P07902
- Ligands
- H2U, ZN
- Pockets
- 5 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Galactose-1-phosphate uridylyltransferase (EC 2.7.7.12) | protein | 344 | 28% helix, 21% strand | P07902 |
Ligands and binding sites
- H2U · 5,6-dihydrouridine-5'-monophosphate · ligand · chains A
- ZN · Zinc ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.56 | 0.77 | 39 | empty |
| 2 | 223 | 0.52 | 0.77 | 34 | empty |
| 3 | 108 | 0.40 | 0.75 | 18 | H2U |
| 4 | 94 | 0.38 | 0.75 | 12 | empty |
| 5 | 87 | 0.37 | 0.76 | 19 | empty |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 6GQD · Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization… · the same entry in another collection · chain A against A, TM-score 1.00
- P07902 · AlphaFold monomer V2.0 prediction for galactose-1-phosphate uridylyltransferase (P07902) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07902
- Elsewhere: RCSB PDB 6GQD · PDBe 6GQD · UniProt P07902
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