Research workbench
Crystal structure of the majin-TERB2 heterotetrameric complex
Analyse Crystal structure of the majin-TERB2 heterotetrameric complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GNY
- Type
- protein
- Length
- 273 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Membrane-anchored junction protein; Telomere repeats-binding bouquet formation protein 2
- UniProt
- Q3KP22, Q8NHR7
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 18% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Membrane-anchored junction protein | protein | 105 | 21% helix, 41% strand | Q3KP22 |
| B | Telomere repeats-binding bouquet formation protein 2 | protein | 30 | 10% helix, 27% strand | Q8NHR7 |
| C | Membrane-anchored junction protein | protein | 107 | 20% helix, 42% strand | Q3KP22 |
| D | Telomere repeats-binding bouquet formation protein 2 | protein | 31 | 10% helix, 26% strand | Q8NHR7 |
Ligands and binding sites
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.56 | 0.80 | 20 | empty |
| 2 | 90 | 0.34 | 0.74 | 21 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1362 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1306 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 458 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 128 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 116 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6GNY · Crystal structure of the MAJIN-TERB2 heterotetrameric complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q3KP22 · AlphaFold monomer V2.0 prediction for membrane-anchored junction protein (Q3KP22) · a predicted model of the same protein · chain A against A, TM-score 0.44
- Q8NHR7 · AlphaFold monomer V2.0 prediction for telomere repeats-binding bouquet formation protein… · a predicted model of the same protein · chain B against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3KP22
- Every structure of UniProt Q8NHR7
- Elsewhere: RCSB PDB 6GNY · PDBe 6GNY · UniProt Q3KP22 · UniProt Q8NHR7
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