Research workbench
Crystal structure of the majin-TERB2 heterotetrameric complex - selenomethionine derivative
Analyse Crystal structure of the majin-TERB2 heterotetrameric complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GNX
- Type
- protein
- Length
- 262 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Membrane-anchored junction protein; Telomere repeats-binding bouquet formation protein 2
- UniProt
- Q3KP22, Q8NHR7
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Membrane-anchored junction protein | protein | 99 | 17% helix, 48% strand | Q3KP22 |
| B | Telomere repeats-binding bouquet formation protein 2 | protein | 32 | 9% helix, 31% strand | Q8NHR7 |
| C | Membrane-anchored junction protein | protein | 100 | 17% helix, 48% strand | Q3KP22 |
| D | Telomere repeats-binding bouquet formation protein 2 | protein | 31 | 10% helix, 32% strand | Q8NHR7 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.49 | 0.77 | 23 | empty |
| 2 | 209 | 0.49 | 0.75 | 27 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1361 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1329 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 391 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 119 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 109 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 6GNX · Crystal structure of the MAJIN-TERB2 heterotetrameric complex - selenomethionine… · the same entry in another collection · chain A against A, TM-score 1.00
- Q3KP22 · AlphaFold monomer V2.0 prediction for membrane-anchored junction protein (Q3KP22) · a predicted model of the same protein · chain A against A, TM-score 0.38
- Q8NHR7 · AlphaFold monomer V2.0 prediction for telomere repeats-binding bouquet formation protein… · a predicted model of the same protein · chain D against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3KP22
- Every structure of UniProt Q8NHR7
- Elsewhere: RCSB PDB 6GNX · PDBe 6GNX · UniProt Q3KP22 · UniProt Q8NHR7
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