Research workbench
Structure of the BTB/POZ domain of human 90K
Analyse Structure of the BTB/POZ domain of human 90K in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GFC
- Type
- protein
- Length
- 722 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galectin-3-binding protein
- UniProt
- H9FUB4
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 5 distinct chains · 47% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Galectin-3-binding protein | protein | 119 | 50% helix, 24% strand | H9FUB4 |
| B | Galectin-3-binding protein | protein | 128 | 45% helix, 22% strand | H9FUB4 |
| D | Galectin-3-binding protein | protein | 123 | 46% helix, 23% strand | H9FUB4 |
| F | Galectin-3-binding protein | protein | 109 | 49% helix, 13% strand | H9FUB4 |
| G | Galectin-3-binding protein | protein | 124 | 44% helix, 23% strand | H9FUB4 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 526 | 0.68 | 0.78 | 33 | empty |
| 2 | 138 | 0.45 | 0.76 | 32 | empty |
| 3 | 93 | 0.39 | 0.76 | 23 | empty |
| 4 | 69 | 0.30 | 0.74 | 15 | empty |
Interfaces
8 interfaces between chains.
- A–B · 1536 Ų buried · 22 hydrogen bonds · protein-protein
- F–G · 1513 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 1468 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 328 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 321 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 6GFC · Structure of the BTB/POZ domain of human 90K · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H9FUB4
- Elsewhere: RCSB PDB 6GFC · PDBe 6GFC · UniProt H9FUB4
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