Research workbench
Crystal structure of a parallel six-helix coiled coil cc-TYPE2-vv
Analyse Crystal structure of a parallel six-helix coiled coil cc-TYPE2-vv in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6G65
- Type
- protein
- Length
- 360 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cc-TYPE2-vv
- Ligands
- ACE, NH2
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Cc-TYPE2-vv | protein | 30 | 93% helix, 0% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · 12 copies · chains A, B, C, D, E, F, G, H, I, J, K, L
- NH2 · Amino group · ion · 12 copies · chains A, D, B, E, C, F, G, J, H, K, I, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 593 | 0.69 | 0.78 | 60 | NH2, ACE |
| 2 | 674 | 0.69 | 0.77 | 64 | ACE |
Interfaces
24 interfaces between chains.
- B–C · 778 Ų buried · 2 hydrogen bonds · protein-protein
- J–K · 759 Ų buried · 4 hydrogen bonds · protein-protein
- D–E · 757 Ų buried · 2 hydrogen bonds · protein-protein
- K–L · 748 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 744 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 covalent (covalent ligand).
Compared structures
- 6G65 · Crystal structure of a parallel six-helix coiled coil CC-Type2-VV · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6G65 · PDBe 6G65
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