Research workbench
Ensemble of 20 structures of the tetrameric mutant of the B1 domain of streptococcal protein G
Analyse Ensemble of 20 structures of the tetrameric mutant of the B1 domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MPE
- Type
- protein
- Length
- 224 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin G binding protein G
- UniProt
- P06654
- Pockets
- 5 · best druggability 0.54
Structure
solution nmr · 1 distinct chain · 23% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Immunoglobulin G binding protein G | protein | 56 | 23% helix, 29% strand | P06654 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.54 | 0.78 | 29 | empty |
| 2 | 102 | 0.49 | 0.81 | 20 | empty |
| 3 | 101 | 0.47 | 0.80 | 19 | empty |
| 4 | 80 | 0.44 | 0.80 | 15 | empty |
| 5 | 70 | 0.43 | 0.81 | 15 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1190 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1187 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 1095 Ų buried · 32 hydrogen bonds · protein-protein
- B–D · 1094 Ų buried · 32 hydrogen bonds · protein-protein
- A–D · 547 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1MPE · Ensemble of 20 structures of the tetrameric mutant of the B1 domain of streptococcal… · the same entry in another collection · chain A against A, TM-score 1.00
- P06654 · AlphaFold monomer V2.0 prediction for immunoglobulin G-binding protein G (P06654) · a predicted model of the same protein · chain A against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06654
- Elsewhere: RCSB PDB 1MPE · PDBe 1MPE · UniProt P06654
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