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NMR solution structure of yeast TSR2(1-152) in complex with S26A(100- 119)

Analyse NMR solution structure of yeast TSR2(1-152) in complex with S26A(100- 119) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6G04
Type
protein
Length
182 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Pre-rRNA-processing protein TSR2; 40S ribosomal protein S26-a
UniProt
Q06672, P39938
Pockets
1 · best druggability 0.50

Structure

solution nmr · 2 distinct chains · 44% helix, 3% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APre-rRNA-processing protein TSR2protein15649% helix, 4% strandQ06672
B40S ribosomal protein S26-aprotein2615% helix, 0% strandP39938

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12060.500.7632empty

Interfaces

1 interface between chains.

  • A–B · 1121 Ų buried · 14 hydrogen bonds · protein-protein

Compared structures

  • 6G04 · NMR Solution Structure of Yeast TSR2(1-152) in Complex with S26A(100-119) · the same entry in another collection · chain A against A, TM-score 1.00
  • Q06672 · AlphaFold monomer V2.0 prediction for pre-rRNA-processing protein TSR2 (Q06672) · a predicted model of the same protein · chain A against A, TM-score 0.88
  • P39938 · AlphaFold monomer V2.0 prediction for 40S ribosomal protein S26-a (P39938) · a predicted model of the same protein · chain B against A, TM-score 0.37

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