Crystal structure of the CHP2 chromoshadow domain in complex with N- terminal domain of chromatin remodeler MIT1

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 35% strand (DSSP).

Ligands and binding sites

• HEZ · Hexane-1,6-diol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• A–C · 1306 Ų buried · 20 hydrogen bonds · protein-protein
• A–B · 638 Ų buried · 7 hydrogen bonds · protein-protein
• B–C · 489 Ų buried · 6 hydrogen bonds · protein-protein

Compared structures

• 6FTO · Crystal structure of the Chp2 chromoshadow domain in complex with N-terminal domain of… · the same entry in another collection · chain A against A, TM-score 1.00
• O42934 · AlphaFold monomer V2.0 prediction for chromo domain-containing protein 2 (O42934) · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q9P793 · AlphaFold monomer V2.0 prediction for chromatin remodeling factor MIT1 (Q9P793) · a predicted model of the same protein · chain C against A, TM-score 0.69

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O42934
• Every structure of UniProt Q9P793
• Elsewhere: RCSB PDB 6FTO · PDBe 6FTO · UniProt O42934 · UniProt Q9P793