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Crystal structure of ssp dnab mini-intein variant M86

Analyse Crystal structure of ssp dnab mini-intein variant M86 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FRH
Type: protein
Length: 310 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replicative DNA HELICASE,REPLICATIVE DNA helicase
EC: 3.6.4.12
UniProt: Q55418
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replicative DNA HELICASE,REPLICATIVE DNA helicase (EC 3.6.4.12)	protein	160	4% helix, 53% strand	Q55418
B	Replicative DNA HELICASE,REPLICATIVE DNA helicase (EC 3.6.4.12)	protein	150	5% helix, 56% strand	Q55418

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	116	0.59	0.85	28	empty
2	108	0.54	0.84	28	empty

Interfaces

1 interface between chains.

A–B · 808 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

6FRH · Crystal structure of Ssp DnaB Mini-Intein variant M86 · the same entry in another collection · chain A against A, TM-score 1.00
Q55418 · AlphaFold monomer V2.0 prediction for replicative DNA helicase (Q55418) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q55418
Elsewhere: RCSB PDB 6FRH · PDBe 6FRH · UniProt Q55418

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