Research workbench
HA1.7 human T-cell receptor specific for influenza virus epitope pkyvkqntlklat presented by human leukocyte antigen HLA-DR0101
Analyse HA1.7 human T-cell receptor specific for influenza virus epitope pkyvkqntlklat… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FR7
- Type
- protein
- Length
- 444 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell receptor alpha chain; T-cell rceceptor beta chain
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-cell receptor alpha chain | protein | 203 | 3% helix, 46% strand | — |
| B | T-cell rceceptor beta chain | protein | 241 | 6% helix, 49% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1117 | 0.73 | 0.76 | 80 | empty |
| 2 | 120 | 0.40 | 0.75 | 18 | empty |
| 3 | 62 | 0.38 | 0.79 | 20 | empty |
| 4 | 64 | 0.32 | 0.75 | 15 | empty |
| 5 | 72 | 0.32 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2062 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6FR7 · HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6FR7 · PDBe 6FR7
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