Research workbench
Inter-alpha-inhibitor heavy chain 1, D298A
Analyse Inter-alpha-inhibitor heavy chain 1, D298A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FPZ
- Type
- protein
- Length
- 1,196 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inter-alpha-trypsin inhibitor heavy chain H1
- UniProt
- P19827
- Pockets
- 13 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Inter-alpha-trypsin inhibitor heavy chain H1 | protein | 598 | 27% helix, 39% strand | P19827 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 571 | 0.77 | 0.84 | 58 | empty |
| 2 | 581 | 0.77 | 0.84 | 53 | empty |
| 3 | 826 | 0.77 | 0.81 | 62 | GOL |
| 4 | 161 | 0.61 | 0.84 | 32 | GOL |
| 5 | 167 | 0.61 | 0.83 | 31 | GOL, ACT |
Interfaces
1 interface between chains.
- A–B · 545 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19827
- Elsewhere: RCSB PDB 6FPZ · PDBe 6FPZ · UniProt P19827
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