Research workbench
Crystal structure of danio rerio LIN41 filamin-nhl domains
Analyse Crystal structure of danio rerio LIN41 filamin-nhl domains in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FPT
- Type
- protein
- Length
- 779 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase TRIM71
- EC
- 2.3.2.27
- UniProt
- E7FAM5
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) | protein | 391 | 5% helix, 47% strand | E7FAM5 |
| B | E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) | protein | 388 | 5% helix, 47% strand | E7FAM5 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1197 | 0.78 | 0.80 | 104 | empty |
| 2 | 956 | 0.77 | 0.80 | 72 | empty |
| 3 | 68 | 0.62 | 0.91 | 24 | empty |
| 4 | 248 | 0.48 | 0.74 | 25 | empty |
| 5 | 239 | 0.48 | 0.74 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1621 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 6FPT · Crystal structure of Danio rerio Lin41 filamin-NHL domains · the same entry in another collection · chain A against A, TM-score 1.00
- E7FAM5 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM71 (E7FAM5) · a predicted model of the same protein · chain B against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E7FAM5
- Elsewhere: RCSB PDB 6FPT · PDBe 6FPT · UniProt E7FAM5
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