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Deoxyguanylosuccinate synthase (dgss) and ATP structure at 1.7 ångström resolution

Analyse Deoxyguanylosuccinate synthase (dgss) and ATP structure at 1.7 ångström… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FM0
Type: protein
Length: 584 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenylosuccinate synthetase
UniProt: G3FFN6
Ligands: ATP
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adenylosuccinate synthetase	protein	294	34% helix, 21% strand	G3FFN6
B	Adenylosuccinate synthetase	protein	290	33% helix, 22% strand	G3FFN6

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	302	0.55	0.76	46	ATP
2	180	0.52	0.79	33	ATP
3	101	0.46	0.79	22	empty
4	69	0.32	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 263 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6FM0 · Deoxyguanylosuccinate synthase (DgsS) and ATP structure at 1.7 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G3FFN6
Elsewhere: RCSB PDB 6FM0 · PDBe 6FM0 · UniProt G3FFN6

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