Research workbench
Yeast MATALPHA2/MCM1/DNA ternary transcription complex crystal structure
Analyse Yeast MATALPHA2/MCM1/DNA ternary transcription complex crystal structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MNM
- Type
- protein + DNA
- Length
- 372 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (STE6 operator DNA); Protein (MCM1 transcriptional regulator); Protein (mat alpha-2…
- UniProt
- P11746, Q6B2C0
- Pockets
- 10 · best druggability 0.68
Structure
x-ray diffraction · 5 distinct chains · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | DNA (STE6 operator DNA) | dna | 26 | — | — |
| F | DNA (STE6 operator DNA) | dna | 26 | — | — |
| A | Protein (MCM1 transcriptional regulator) | protein | 85 | 48% helix, 14% strand | P11746 |
| B | Protein (MCM1 transcriptional regulator) | protein | 81 | 54% helix, 14% strand | P11746 |
| C, D | Protein (mat alpha-2 transcriptional repressor) | protein | 77 | 51% helix, 10% strand | Q6B2C0 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.68 | 0.84 | 33 | empty |
| 2 | 359 | 0.62 | 0.78 | 31 | empty |
| 3 | 77 | 0.59 | 0.89 | 16 | empty |
| 4 | 184 | 0.48 | 0.76 | 26 | empty |
| 5 | 93 | 0.46 | 0.80 | 19 | empty |
Interfaces
12 interfaces between chains.
- A–B · 1922 Ų buried · 14 hydrogen bonds · protein-protein
- E–F · 1117 Ų buried · 95 hydrogen bonds · nucleic-nucleic
- B–C · 711 Ų buried · 9 hydrogen bonds · protein-protein
- F–C · 586 Ų buried · 14 hydrogen bonds · protein-nucleic
- F–B · 577 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 1MNM · Yeast MATALPHA2/MCM1/DNA ternary transcription complex crystal structure · the same entry in another collection · chain D against D, TM-score 1.00
- P11746 · AlphaFold monomer V2.0 prediction for pheromone receptor transcription factor (P11746) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11746
- Every structure of UniProt Q6B2C0
- Elsewhere: RCSB PDB 1MNM · PDBe 1MNM · UniProt P11746 · UniProt Q6B2C0
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