Research workbench
Schistosoma mansoni phosphodiesterase 4A
Analyse Schistosoma mansoni phosphodiesterase 4A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FG5
- Type
- protein
- Length
- 659 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphodiesterase
- EC
- 3.1.4.-
- UniProt
- G4VPI6
- Ligands
- ZN, MG
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphodiesterase (EC 3.1.4.-) | protein | 334 | 66% helix, 0% strand | G4VPI6 |
| B | Phosphodiesterase (EC 3.1.4.-) | protein | 325 | 67% helix, 0% strand | G4VPI6 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 973 | 0.76 | 0.79 | 101 | MG |
| 2 | 420 | 0.72 | 0.82 | 45 | MG |
Interfaces
1 interface between chains.
- A–B · 722 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 6FG5 · Schistosoma mansoni Phosphodiesterase 4A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G4VPI6
- Elsewhere: RCSB PDB 6FG5 · PDBe 6FG5 · UniProt G4VPI6
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