Research workbench
Crystal structure of R. ruber adh-a, mutant F43H
Analyse Crystal structure of R. ruber adh-a, mutant F43H in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FFX
- Type
- protein
- Length
- 1,384 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alcohol dehydrogenase
- UniProt
- A0A1Q8I6M1
- Ligands
- NAD, ZN
- Pockets
- 13 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Alcohol dehydrogenase | protein | 346 | 29% helix, 25% strand | A0A1Q8I6M1 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 4 copies · chains A, D, B, C
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 874 | 0.82 | 0.84 | 126 | empty |
| 2 | 771 | 0.76 | 0.80 | 71 | ZN, NAD |
| 3 | 824 | 0.76 | 0.80 | 70 | NAD |
| 4 | 739 | 0.75 | 0.80 | 67 | NAD |
| 5 | 775 | 0.75 | 0.79 | 73 | NAD |
Interfaces
6 interfaces between chains.
- B–C · 1485 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 1463 Ų buried · 21 hydrogen bonds · protein-protein
- B–D · 691 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 656 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 464 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6FFX · Crystal structure of R. ruber ADH-A, mutant F43H · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1Q8I6M1
- Elsewhere: RCSB PDB 6FFX · PDBe 6FFX · UniProt A0A1Q8I6M1
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