Research workbench
Neutron structure of human transthyretin (ttr) S52P mutant in complex with tafamidis at room temperature to 2A resolution (quasi-laue)
Analyse Neutron structure of human transthyretin (ttr) S52P mutant in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FFT
- Type
- protein
- Length
- 232 residues
- Chains
- 2
- Method
- x-ray diffraction; neutron diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Ligands
- 3MI
- Pockets
- 3 · best druggability 0.32
Structure
x-ray diffraction; neutron diffraction · 1 distinct chain · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 116 | 6% helix, 53% strand | P02766 |
Ligands and binding sites
- 3MI · 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.32 | 0.76 | 16 | empty |
| 2 | 67 | 0.32 | 0.75 | 14 | empty |
| 3 | 55 | 0.26 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 931 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6FFT · Neutron structure of human transthyretin (TTR) S52P mutant in complex with tafamidis at… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 6FFT · PDBe 6FFT · UniProt P02766
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