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Crystal structure of drosophila neural ectodermal development factor imp-L2 with drosophila DILP5 insulin

Analyse Crystal structure of drosophila neural ectodermal development factor imp-L2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FEY
Type: protein
Length: 841 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NEURAL/ECTODERMAL development factor imp-L2; Probable insulin-like peptide 5
UniProt: Q09024, Q7KUD5
Pockets: 8 · best druggability 0.83

Structure

x-ray diffraction · 12 distinct chains · 11% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NEURAL/ECTODERMAL development factor imp-L2	protein	196	2% helix, 50% strand	Q09024
B	NEURAL/ECTODERMAL development factor imp-L2	protein	207	0% helix, 47% strand	Q09024
D	NEURAL/ECTODERMAL development factor imp-L2	protein	160	0% helix, 48% strand	Q09024
C	NEURAL/ECTODERMAL development factor imp-L2	protein	124	2% helix, 28% strand	Q09024
E	Probable insulin-like peptide 5	protein	21	62% helix, 0% strand	Q7KUD5
F	Probable insulin-like peptide 5	protein	19	58% helix, 0% strand	Q7KUD5
G	Probable insulin-like peptide 5	protein	20	60% helix, 5% strand	Q7KUD5
H	Probable insulin-like peptide 5	protein	19	58% helix, 0% strand	Q7KUD5
I	Probable insulin-like peptide 5	protein	20	65% helix, 0% strand	Q7KUD5
J	Probable insulin-like peptide 5	protein	14	79% helix, 0% strand	Q7KUD5
K	Probable insulin-like peptide 5	protein	23	22% helix, 0% strand	Q7KUD5
L	Probable insulin-like peptide 5	protein	18	61% helix, 0% strand	Q7KUD5

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	903	0.83	0.85	88	empty
2	348	0.71	0.84	48	empty
3	1173	0.70	0.74	90	empty
4	283	0.62	0.80	42	empty
5	119	0.45	0.78	25	empty

Interfaces

21 interfaces between chains.

A–B · 1502 Å² buried · 15 hydrogen bonds · protein-protein
D–C · 651 Å² buried · 4 hydrogen bonds · protein-protein
E–F · 373 Å² buried · 2 hydrogen bonds · protein-protein
B–H · 358 Å² buried · 0 hydrogen bonds · protein-protein
A–I · 356 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 20 disulfide (disulfide).

Compared structures

6FEY · Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q09024
Every structure of UniProt Q7KUD5
Elsewhere: RCSB PDB 6FEY · PDBe 6FEY · UniProt Q09024 · UniProt Q7KUD5

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