Research workbench

Unc-51-like kinase 3 (ULK3) in complex with momelotinib

Analyse Unc-51-like kinase 3 (ULK3) in complex with momelotinib in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FDZ
Type: protein
Length: 265 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase ULK3
EC: 2.7.11.1
UniProt: Q6PHR2
Ligands: C87
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U	SERINE/THREONINE-protein kinase ULK3 (EC 2.7.11.1)	protein	265	34% helix, 18% strand	Q6PHR2

Ligands and binding sites

C87 · Momelotinib · ligand · chains U

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	566	0.75	0.82	63	C87
2	69	0.34	0.75	14	empty

Compared structures

6FDZ · Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib · the same entry in another collection · chain U against U, TM-score 1.00
Q6PHR2 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase ULK3 (Q6PHR2) · a predicted model of the same protein · chain U against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6PHR2
Elsewhere: RCSB PDB 6FDZ · PDBe 6FDZ · UniProt Q6PHR2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.