Research workbench
Monoclonal antibody targeting matrix metalloproteinase 7
Analyse Monoclonal antibody targeting matrix metalloproteinase 7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FBJ
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heavy chain; Light chain
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Heavy chain | protein | 214 | 8% helix, 50% strand | — |
| L | Light chain | protein | 213 | 6% helix, 49% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.65 | 0.75 | 62 | empty |
| 2 | 69 | 0.44 | 0.81 | 16 | empty |
| 3 | 63 | 0.31 | 0.75 | 17 | empty |
| 4 | 54 | 0.28 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- H–L · 1911 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6FBJ · monoclonal antibody targeting Matrix metalloproteinase 7 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6FBJ · PDBe 6FBJ
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