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Three-dimensional structure of murine anti-P- azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten

Analyse Three-dimensional structure of murine anti-P- azophenylarsonate Fab 36-71. 1.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FAB
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: IGG1-kappa 36-71 Fab (light chain); IGG1-kappa 36-71 Fab (heavy chain)
UniProt: P01837
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	IGG1-kappa 36-71 Fab (light chain)	protein	214	6% helix, 49% strand	P01837
H	IGG1-kappa 36-71 Fab (heavy chain)	protein	222	5% helix, 52% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	211	0.45	0.74	26	empty
2	54	0.24	0.72	12	empty

Interfaces

1 interface between chains.

L–H · 2079 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6FAB · Three-dimensional structure of murine anti-P-azophenylarsonate Fab 36-71. 1. X-ray… · the same entry in another collection · chain L against L, TM-score 1.00
P01837 · AlphaFold monomer V2.0 prediction for immunoglobulin kappa constant (P01837) · a predicted model of the same protein · chain L against A, TM-score 0.49

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01837
Elsewhere: RCSB PDB 6FAB · PDBe 6FAB · UniProt P01837

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