Research workbench
Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide from calsyntenin-1
Analyse Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6F9I
- Type
- protein
- Length
- 544 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin light chain 2; Calsyntenin-1
- UniProt
- Q91YS4, Q9EPL2
- Pockets
- 6 · best druggability 0.40
Structure
x-ray diffraction · 4 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin light chain 2 | protein | 261 | 81% helix, 0% strand | Q91YS4 |
| X | Calsyntenin-1 | protein | 9 | 0% helix, 0% strand | Q9EPL2 |
| B | Kinesin light chain 2 | protein | 264 | 82% helix, 0% strand | Q91YS4 |
| C | Calsyntenin-1 | protein | 10 | 0% helix, 0% strand | Q9EPL2 |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.40 | 0.79 | 21 | empty |
| 2 | 78 | 0.39 | 0.78 | 17 | empty |
| 3 | 80 | 0.38 | 0.77 | 18 | empty |
| 4 | 59 | 0.31 | 0.75 | 10 | empty |
| 5 | 56 | 0.30 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- B–C · 744 Ų buried · 10 hydrogen bonds · protein-protein
- A–X · 676 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 506 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6F9I · Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide from… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9EPL2 · AlphaFold monomer V2.0 prediction for calsyntenin-1 (Q9EPL2) · a predicted model of the same protein · chain X against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91YS4
- Every structure of UniProt Q9EPL2
- Elsewhere: RCSB PDB 6F9I · PDBe 6F9I · UniProt Q91YS4 · UniProt Q9EPL2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.