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Model of the rift valley fever virus glycoprotein pentamer

Analyse Model of the rift valley fever virus glycoprotein pentamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6F9F
Type
protein
Length
3,660 residues
Chains
10
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Glycoprotein
UniProt
A2T085, A2T072
Pockets
20 · best druggability 0.80

Structure

electron microscopy · 2 distinct chains · 7% helix, 40% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, C, E, G, IGlycoproteinprotein30111% helix, 27% strandA2T085
B, D, F, H, JGlycoproteinprotein4315% helix, 50% strandA2T072

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
111340.800.81120empty
210410.800.8190empty
310570.800.81108empty
49900.790.8190empty
57840.790.8273empty

Interfaces

25 interfaces between chains.

  • A–B · 1149 Ų buried · 15 hydrogen bonds · protein-protein
  • G–H · 1112 Ų buried · 10 hydrogen bonds · protein-protein
  • I–J · 1084 Ų buried · 9 hydrogen bonds · protein-protein
  • C–D · 1040 Ų buried · 15 hydrogen bonds · protein-protein
  • E–F · 1031 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

  • 6F9F · Model of the Rift Valley fever virus glycoprotein pentamer · the same entry in another collection · chain A against A, TM-score 1.00

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