Research workbench

Thermotoga maritima glutamate dehydrogenase mutant N97D, G376K

Analyse Thermotoga maritima glutamate dehydrogenase mutant N97D, G376K in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1B3B
Type: protein
Length: 2,454 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (glutamate dehydrogenase)
EC: 1.4.1.3
UniProt: P96110
Pockets: 14 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Protein (glutamate dehydrogenase) (EC 1.4.1.3)	protein	409	49% helix, 16% strand	P96110

Pockets

14 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1171	0.84	0.86	92	empty
2	1156	0.84	0.86	92	empty
3	1103	0.84	0.85	95	empty
4	1048	0.80	0.81	119	empty
5	1088	0.78	0.80	105	empty

Interfaces

12 interfaces between chains.

A–F · 1031 Å² buried · 16 hydrogen bonds · protein-protein
B–E · 1030 Å² buried · 15 hydrogen bonds · protein-protein
C–D · 1018 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 895 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 879 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1B3B · Thermotoga maritima glutamate dehydrogenase mutant N97D, G376K · the same entry in another collection · chain C against C, TM-score 1.00
P96110 · AlphaFold monomer V2.0 prediction for glutamate dehydrogenase (P96110) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P96110
Elsewhere: RCSB PDB 1B3B · PDBe 1B3B · UniProt P96110

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