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A heterotetramer of human HSPB2 and HSPB3

Analyse A heterotetramer of human HSPB2 and HSPB3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6F2R
Type: protein
Length: 1,330 residues
Chains: 21
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HSPB2,HEAT shock protein beta-2,HEAT shock protein beta-2, heat shock protein beta-2,HEAT…
UniProt: Q16082, Q12988
Pockets: 12 · best druggability 0.82

Structure

x-ray diffraction · 11 distinct chains · 0% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, E, I	HSPB2,HEAT shock protein beta-2,HEAT shock protein beta-2, heat shock protein beta-2,HEAT shock protein beta-2,HEAT shock protein beta-2	protein	130	0% helix, 28% strand	Q16082
C, G, K	HSPB2,HEAT shock protein beta-2,HEAT shock protein beta-2, heat shock protein beta-2,HEAT shock protein beta-2,HEAT shock protein beta-2	protein	121	0% helix, 38% strand	Q16082
D	Heat shock protein beta-2	protein	80	4% helix, 38% strand	Q16082
T, V	Heat shock protein beta-3,HEAT shock protein beta-3,HEAT shock protein beta-3,HEAT shock protein beta-3,HEAT shock protein beta-2	protein	88	0% helix, 33% strand	Q12988
M	Unknown peptide from HSPB2 or HSPB3	protein	10	0% helix, 0% strand	—
N	Unknown peptide from HSPB2 or HSPB3	protein	7	0% helix, 0% strand	—
O	Unknown peptide from HSPB2 or HSPB3	protein	6	0% helix, 0% strand	—
Q	Heat shock protein beta-3,HEAT shock protein beta-3,HEAT shock protein beta-3,HEAT shock protein beta-3,HEAT shock protein beta-2	protein	89	0% helix, 37% strand	Q12988
F, J	Heat shock protein beta-2	protein	79	0% helix, 38% strand	Q16082
1, 2, 3	Unknown peptide from HSPB2 or HSPB3	protein	5	0% helix, 0% strand	—
W, X, Y	Unknown peptide from HSPB2 or HSPB3	protein	12	0% helix, 0% strand	—

Pockets

12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1020	0.82	0.83	111	empty
2	1117	0.80	0.81	122	empty
3	949	0.79	0.82	116	empty
4	1133	0.79	0.81	112	empty
5	1101	0.78	0.80	101	empty

Interfaces

43 interfaces between chains.

A–C · 1114 Å² buried · 20 hydrogen bonds · protein-protein
E–G · 1104 Å² buried · 17 hydrogen bonds · protein-protein
I–K · 1053 Å² buried · 19 hydrogen bonds · protein-protein
I–V · 725 Å² buried · 17 hydrogen bonds · protein-protein
A–Q · 699 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6F2R · A heterotetramer of human HspB2 and HspB3 · the same entry in another collection · chain M against M, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16082
Every structure of UniProt Q12988
Elsewhere: RCSB PDB 6F2R · PDBe 6F2R · UniProt Q16082 · UniProt Q12988

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