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Crystal structure of olive flounder [paralichthys olivaceus] interferon gamma at 2.3 ångström resolution

Analyse Crystal structure of olive flounder [paralichthys olivaceus] interferon gamma… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6F1E
Type: protein
Length: 270 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interferon gamma
UniProt: B3IXK1
Pockets: 4 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interferon gamma	protein	143	71% helix, 0% strand	B3IXK1
B	Interferon gamma	protein	127	76% helix, 0% strand	B3IXK1

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.52	0.81	23	empty
2	76	0.41	0.79	15	empty
3	50	0.27	0.75	11	empty
4	52	0.26	0.73	11	empty

Interfaces

1 interface between chains.

A–B · 4233 Å² buried · 35 hydrogen bonds · protein-protein

Compared structures

6F1E · Crystal structure of olive flounder [Paralichthys olivaceus] interferon gamma at 2.3… · the same entry in another collection · chain A against A, TM-score 1.00
B3IXK1 · AlphaFold monomer V2.0 prediction for interferon gamma (B3IXK1) · a predicted model of the same protein · chain A against A, TM-score 0.84

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Every structure of UniProt B3IXK1
Elsewhere: RCSB PDB 6F1E · PDBe 6F1E · UniProt B3IXK1

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