Research workbench
Crystal structure of dotm cytoplasmic domain (residues 153-380) semet derivative
Analyse Crystal structure of dotm cytoplasmic domain (residues 153-380) semet derivative in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EXD
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Icmp (dotm)
- UniProt
- Q5ZYC7
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Icmp (dotm) | protein | 214 | 63% helix, 3% strand | Q5ZYC7 |
| B | Icmp (dotm) | protein | 220 | 63% helix, 3% strand | Q5ZYC7 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.40 | 0.79 | 16 | empty |
| 2 | 79 | 0.29 | 0.72 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 287 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 6EXD · Crystal structure of DotM cytoplasmic domain (residues 153-380) SeMet derivative · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZYC7
- Elsewhere: RCSB PDB 6EXD · PDBe 6EXD · UniProt Q5ZYC7
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