Research workbench
Crystal structure of dotm cytoplasmic domain (residues 153-380), R314E/R315E
Analyse Crystal structure of dotm cytoplasmic domain (residues 153-380), R314E/R315E in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EXC
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Icmp (dotm)
- UniProt
- Q5ZYC7
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Icmp (dotm) | protein | 219 | 62% helix, 3% strand | Q5ZYC7 |
| B | Icmp (dotm) | protein | 207 | 64% helix, 4% strand | Q5ZYC7 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.55 | 0.84 | 22 | empty |
| 2 | 60 | 0.49 | 0.86 | 16 | empty |
| 3 | 90 | 0.42 | 0.78 | 21 | empty |
| 4 | 91 | 0.41 | 0.77 | 19 | empty |
| 5 | 92 | 0.38 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 808 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6EXC · Crystal structure of DotM cytoplasmic domain (residues 153-380),R314E/R315E · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZYC7
- Elsewhere: RCSB PDB 6EXC · PDBe 6EXC · UniProt Q5ZYC7
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